In accordance with the guidelines for precocious puberty, it is advisable to have a detailed assessment of bone age, because it is difficult to identify the growth of bone age without a detailed assessment at short intervals, which is not conducive to dose adjustment. The dose adjustment of GnRHa is mainly in the first six months, and after six months, if there is no special change, it is usually once every six months, and the review items are the same as the review at six months. At present, in GnRHa treatment for more than two months when the review, from time to time, using the method of checking the sex hormone about 1 hour after the injection of GnRHa, so equivalent to a simple stimulation test (the first dose has been enhanced, the injection of the third injection is often less than 1.5 months, generally do not check the value of one hour after the injection), unless the treatment is not smooth, when the review, generally rarely do the standardized GnRH stimulation test again. GnRHa discontinuation indicators: application is generally not less than two years, in the bone age and age, and reached or close to the age of normal sexual development, the predicted height slightly higher than the target height (generally to be 2 ~ 3cm higher) can be considered to stop the drug. For girls, discontinuation of the drug is generally considered when the bone age is not too great, the age is greater than 10 years old, and the height is around 150 CM. Because there is still 2~3 months of slower bone growth time after stopping the drug, but some people may have a faster bone growth period in the following 2~4 months, and the later rapid bone growth may lower the predicted height. Or stop the drug when the bone age of girls is more than 13.5 years old, boys bone age is more than 14.5 years old, even if the combination of growth hormone, can not play a role in improving lifelong height, but growth hormone can be considered to continue to use. When the GnRHa discontinuation index is reached, the drug can be directly discontinued, and generally no special examination is needed.