A red and sore nose indicates inflammation, which is usually caused by bacterial or anaerobic infections, and may be due to the patient’s frequent picking of the nose with his hands and repeated rubbing of the nose. In terms of treatment, patients need to take oral cephalosporin antibiotics. Before using the drug, patients need to ask if there is any history of allergy to cephalosporins, and they must not drink alcohol while taking cephalosporins. Cefixime capsules or cefprozil capsules are more commonly used in clinical practice. Patients can also purchase Bactrim ointment to apply on the surface of the nose three times a day. Before going to bed, patients can apply metronidazole gel to the surface of the nose, which can effectively act as an anti-anaerobic bacteria. After active treatment, the patient’s condition will improve significantly in a week or so. In life, it is important to pay attention to hand hygiene and not to rub the nose with hands repeatedly.