The human papillomavirus (HPV) infection of the plantar skin causes disease, mainly through direct or indirect contact transmission, the lesions are initially small shiny papules, gradually increasing to soybean size or larger, due to pressure and the formation of yellowish or maroon callus-like plaques or flat papules, the surface is rough, well-defined, the edge around a slightly higher keratin ring, after removing the keratin layer, there is a loose keratin soft core underneath, visible After removing the keratin layer, there are loose keratinous soft cores underneath, and small black dots formed by ruptured capillaries and bleeding, which are painful. If it contains more than one keratinous core, it is called a mosaic wart. The main treatment of toe warts is physical therapy and topical medication, internal medication for the number of lesions or a long time to cure. 2, topical drug treatment: can try Pingyangmycin wart root injection once a week, applicable to refractory toe warts. 3, internal drug treatment: there is no effective anti-HPV drugs, can try immunomodulators (such as interferon, BCG polysaccharide nucleic acid preparations, levamisole, etc.); Chinese medicine to clear heat detoxification, dispersing wind and liver, dispersion as the rule, sometimes can get a better effect. 4, in addition, for children or intolerant to pain, photodynamic therapy is feasible.