1. High-voltage electrical burns combined with hypothalamic injury are clinically rare, 2. High-voltage electrical burns combined with hypothalamic injury can lead to a significant decrease in the patient’s immunity, and electrical burn wounds are prone to early bacterial invasive infection. Trauma treatment should be timely and immune support should be given. 3, central hyperthermia, the lower thalamus has thermoregulatory functions, when the lower thalamus anterior damage, the body heat dissipation dysfunction, can appear central hyperthermia, body temperature often rises suddenly, up to 41 ℃ or even 42 ℃, but the skin is dry and less sweaty, uneven distribution of skin temperature, the extremities are lower than the trunk, and no inflammation and toxic manifestations, antipyretic drugs are also ineffective; its posterior injury appears to produce heat and insulation failure and cause body temperature Hypothermia: if combined with nodal injury, there can be metabolic disorders of the body, the body temperature will be further reduced, such as extensive damage to the lower thalamus, the body temperature rises and falls accordingly with the ambient temperature. Irritability should be used in adequate amounts of sedation and physical cooling, and keep the airway open. 4, endocrine metabolic dysfunction, damage to the subthalamic supraoptic nucleus, paraventricular nucleus or pituitary stalk supraoptic nucleus-pituitary bundle involvement, resulting in impaired synthesis and release of antidiuretic hormone, causing central urinary collapse, daily urine volume of 4000-10000ml or more, urine specific gravity below 1.005. maintain the maintenance of water, electrolyte balance is very important, timely control of rehydration, potassium and sodium supplementation, glucocorticoid therapy and gradually Reduce the amount gradually. 5. The coagulation system is abnormal, platelets are progressively reduced, fibrinogen is significantly reduced, and dimer is increased. Give low molecular heparin treatment and pay attention to the detection of prothrombin time. 6, hypothalamic injury from the subthalamic anterior region to the dorsal nucleus of the vagus nerve of the medulla oblongata there is a nerve bundle, management of the upper gastrointestinal autonomic nerve, any of its damage can cause upper gastrointestinal lesions. Therefore, when severe traumatic brain injury involves the lower thalamus, it is easy to cause gastric and duodenal mucosal erosion, necrosis, ulceration and bleeding. The cause may be vasoconstriction and ischemia of the upper gastrointestinal tract, or overexcitation of the vagus nerve, or hyper-secretion of gastrin and high gastric acid. In addition, a large amount of glucocorticoid application is also likely to cause upper gastrointestinal bleeding, therefore, early prevention of upper gastrointestinal bleeding is crucial, and lansoprazole was applied throughout the treatment in this patient.