Occasionally, a slightly high percentage of naive granulocytes may be physiologically elevated and requires no special treatment. If the percentage of naive granulocytes is persistently high or exceeds the normal range, it may be due to disease and other factors. It is recommended that patients promptly go to the hematology department of the hospital, under the guidance of the doctor to conduct a full blood test to clarify the cause of the disease, and then deal with the cause. The common clinical causes of high percentage of naive granulocytes are: 1. Chronic granulocytic leukemia: usually manifests as an increased white blood cell count, with an increased percentage of naive granulocytes being the main cause. Patients may experience dizziness and weakness, shortness of breath after activity, easy bleeding, menstrual disorders, etc.; 2. Acute myeloid leukemia: manifests as monocytosis and high percentage of naive granulocytes. Patients have clinical symptoms such as pale skin, loss of appetite and weakness; 3. Myelodysplastic syndrome: manifests as blood cytopenia, high percentage of naive granulocytes and abnormal proliferation of megakaryocytes. Patients may have symptoms such as shortness of breath, dizziness, etc. 4, anemia: for example, hemolytic anemia and megaloblastic anemia may have high percentage of naïve granulocytes, and patients may have symptoms related to anemia such as pale skin mucous membrane and shortness of breath. 5, allergic purpura: patients may have normal or increased white blood cells, high percentage of naïve granulocytes and increased neutrophils. The patient’s skin mucous membrane may appear plaques, accompanied by rash, abdominal pain and other symptoms; 6, other: upper respiratory tract infection, bacterial infection, white-like reaction, bone marrow fibrosis, large burns, tumors, AIDS, etc. can lead to high percentage of naïve granulocytes.