The therapeutic drugs for recurrent mediastinal lymph node enlargement after lung adenocarcinoma surgery include chemotherapeutic drugs, targeted drugs, immune drugs, symptom-reducing drugs and so on. 1. Chemotherapeutic drugs: at present, the commonly used drugs in clinic include pemetrexed, paclitaxel, doxorubicin, gemcitabine, cisplatin, carboplatin, etc. Patients with good physique are mostly used pemetrexed in combination with cisplatin, or paclitaxel in combination with cisplatin. 2. Targeted drugs currently used in lung adenocarcinoma: including gefitinib, afatinib, ositinib, crizotinib, and erlotinib. 3. Immunologic drugs: mainly include pembrolizumab, atilizumab, natalizumab and so on. 4. Symptom-reducing drugs: mainly refer to opioid or non-opioid analgesics used for controlling the pain of lung adenocarcinoma, such as morphine, oxycodone extended-release tablets, fentanyl, acetaminophen and so on. There are many kinds of drugs for different conditions, patients need to consult doctor and follow the doctor’s instruction to choose.