The prognosis of nephrotic syndrome varies widely among individuals, and according to the type of pathology, the best cure is found in microscopic lesion nephropathy and mild thylakoid proliferative glomerulonephritis. In contrast, the prognosis of membranous capillary glomerulonephritis and severe membranoproliferative glomerulonephritis is poorer, and the progression to chronic renal failure is faster. Primary nephrotic syndrome manifests different types of pathological changes, and the common ones are: microscopic lesion nephropathy; thylakoid proliferative glomerulonephritis; focal segmental glomerulosclerosis; membranous nephropathy; and thylakoid capillary glomerulonephritis. For the pathologic types, microscopic lesion nephropathy and mild thylakoid proliferative glomerulonephritis are generally better treated. In addition to the pathologic type affecting the prognosis of nephrotic syndrome, poorly controlled clinical symptoms such as massive proteinuria, hypertension, and hyperlipidemia may easily lead to glomerulosclerosis and cause poor prognosis. In the process of disease progression, repeated infections, thromboembolism and other complications will also have a negative impact on the prognosis of nephrotic syndrome. Nephrotic syndrome is harmful to kidney health, and it can occur in children, adolescents, middle-aged and elderly people, and some types of the disease are more insidious, therefore, regular medical checkups are very important. Therefore, regular medical checkups are very important. Patients with nephrotic syndrome are advised to go to regular hospitals in time and receive standardized treatment under the guidance of physicians.