Diabetic nephropathy is usually not completely cured in the early stage, but it can be controlled by standardized treatment to slow down the progression of kidney disease, improve the quality of life of patients and prolong life. Diabetic nephropathy is a diabetic microangiopathy, which is the main cause of end-stage renal failure. Diabetic nephropathy is divided into 5 stages in total, and the early stage mainly refers to the first 3 stages of diabetic nephropathy. When diabetic nephropathy occurs, the first step is to carry out hypoglycemic treatment to control blood glucose in the ideal range. For diabetic patients taking oral hypoglycemic drugs, hypoglycemic drugs with the ability to protect renal function and reduce urinary protein, such as gliclazide, are preferred. It can also be used with ACEI drugs to protect the kidneys, such as enalapril. If oral hypoglycemic drugs cannot be taken, it is recommended to use insulin as early as possible. All the above medications should be used under doctor’s guidance, avoid self-medication. Patients with diabetic nephropathy are advised to go to regular hospitals in time and receive standardized treatment under doctors’ guidance.