The “slimming needle” and “wrinkle needle” that beauty seekers talk about are mostly referred to as botulinum toxin, because the name of the word botulinum toxin sounds very scary, reminiscent of the toxin’s harm to the body, many beauty seekers first heard the name of the drug on Many beauty seekers are discouraged and discouraged when they first hear the name of this drug. Is it really toxic? Can it really be used for cosmetic purposes?
Botulinum toxin (creatoxin or krotoxin) is a bacterial exotoxin produced by the bacterium Clostridium botulinum (Clostridium botulinum). Clostridium botulinum grows in an oxygen-deprived environment and is extremely viable in canned foods and sealed pickled foods, making it one of the most virulent bacteria. Clostridium botulinum is a deadly germ that secretes botulinum toxin during reproduction, which is the most virulent toxin known, inhibiting the release of acetylcholine from cholinergic nerve endings, leading to muscle relaxation-type paralysis, and even death after respiratory muscle paralysis. See here is not a bigger question? So toxic poison used for beauty is not crazy!
As early as 1817, Dr. Kerner in Germany first described the signs and symptoms of botulism caused by food, and in severe cases, death by suffocation after muscle paralysis, and suggested the possibility of using botulinum toxin to treat dystonia and autonomic disorders. In 1920, Dr. Sommer in the United States first extracted botulinum toxin type A. On the basis of this, Professor Schantz, a leading American botulinum toxin expert, made botulinum toxin type A crystals in 1946.
In the 1970s, Dr. Scott, an American ophthalmologist, was inspired by the earliest appearance of ocular symptoms in patients with botulism and the subsequent slow recovery, and envisioned the use of botulinum toxin for ophthalmic diseases. After successful animal experiments in collaboration with Schantz, he began to treat spastic strabismus with botulinum toxin type A, which was later extended to neurological and otorhinolaryngological conditions such as facial spasm, spastic squint, and limb dystonia. In 1989, the U.S. Food and Drug Administration (FDA) first approved Botulinum toxin type A, jointly developed by Scott and Schantz, as a clinical treatment, which was the first microbial toxin to be used clinically in the world.
Jean Carruthers, a Canadian ophthalmologist, accidentally noticed the disappearance of wrinkles around the patient’s eyes when using botulinum toxin type A to treat eye spasms in 1986, and thus used botulinum toxin for cosmetic purposes together with her husband Alastair Carruthers. He became the founder of botulinum toxin cosmetology.
In 2002, the US FDA approved Botulinum toxin type A for cosmetic use, and in 2012, the Chinese CFDA also approved it, with an annual growth rate of over 100% since its approval in 2002, and it is regarded as “the main method for cosmetic wrinkle removal in the 21st century”. It is regarded as “the main method of cosmetic wrinkle removal in the 21st century”.
Botulinum toxin is used for cosmetic purposes, so does its toxicity really have no effect on the human body? At present, BOTOX from the United States, Dysport from the United Kingdom and BTXA from China have the highest market share and are the most commonly used type A botulinum toxins. Take Botox as an example, according to the experimental data of 20g mice, the half lethal dose for 70kg adults should be 50U/kg, i.e. about 3500U. The lethal dose should be 40U/kg, i.e. about 2800U. And even the largest amount of clinical thin calves, the use of only 200U-400U, from the lethal amount is still far from, so find a regular medical institutions, doctors, botulinum toxin can be used with confidence.
After years of clinical practice, Botox has expanded its range of applications based on its utility characteristics compared to two decades ago, and generally speaking, Botox is now found to have the following roles.
1, relaxation of skeletal muscle: to achieve the effect of preventing the contraction of expression muscle and eliminating wrinkles; to make muscle disuse atrophy, reduce volume and improve local contour; to break the dynamic balance of muscle and adjust facial expression; to paralyze the downward pulling effect of muscle and enhance the face.
2.Inhibit gland secretion: inhibit sweat sebaceous gland secretion, which can improve skin quality and treat hand and foot hyperhidrosis and axillary odor.
3.Reducing pain: Botulinum toxin injection has become the first choice for the treatment of migraine.
4.Inhibit scarring: It has a direct inhibitory effect on scarring and can reduce scarring by inhibiting muscle contraction around surgical incisions or scars.
Botulinum toxin is currently used in the following common cosmetic applications.
1, reduce wrinkles: such as forehead lines, frown lines, crow’s feet, nasal dorsal lines, perioral lines, transverse neck lines, chin pebble-like ugly.
2, reduce the local contour: thin bite muscle, thin calf, eliminate eye moss, eliminate turkey neck.
3.Adjustment of facial expression: lifting the corners of the mouth (smiling lips), lowering the upper lip (improving gingival smile), lifting the nose, narrowing the nostrils.
4.Lift the face: lift the eyebrows, lift the middle and lower face.
5.Improve skin quality: inhibit sebaceous gland secretion, treat acne, and make skin delicate.
6.Treat hyperhidrosis of hands and feet, armpit odor.
7.Inhibit scarring.
In short, Botox is not as scary as its name, as long as it can be applied correctly, it is the most convenient, safe and effective means of beauty, is benefiting people who love beauty, and with the depth of application research, there will be more and better services for human beings.