There are many causes of pancreatitis, such as: cholelithiasis, alcoholism, overeating and so on. 1. Cholelithiasis: Cholelithiasis is the main cause of pancreatitis in China. When gallstones enter the bile duct and block the sphincter of Oddi, the digestive enzymes secreted by the pancreas cannot be discharged into the digestive tract through the pancreatic duct, and the digestive enzymes will damage the pancreas’s own cells, destroying the pancreatic tissues, releasing more digestive enzymes, and accelerating the development of the condition. 2. Alcoholism: the main component of alcohol is ethanol, which leads to the accumulation of digestive enzymes in the pancreatic cells and their premature activation and release, increases the permeability of the pancreatic ducts, and makes the digestive enzymes reach the thin walls of the tissues and cause tissue damage. 3. Overeating: When you eat a lot of protein and high-fat food at one time, your body will promote the pancreas to secrete a lot of digestive enzymes such as pancreatic protease and pancreatic lipase, etc. When the pancreatic ducts are blocked or the pressure in the bile ducts is high, the digestive enzymes will be retained inside the pancreas and self-digested, which damages the pancreas and leads to pancreatitis. There are many other causes of pancreatitis, so it is recommended to consult a doctor in time and avoid blindly using medication on your own.