There are many types of glucose-lowering drugs in use in the clinic, including oral hypoglycemic agents and subcutaneous formulations, each with corresponding indications and contraindications, and patients with diabetes need to prevent hypoglycemia during administration.
There are many types of glucose-lowering drugs in use in the clinic, including proinsulin secretagogues, biguanides, thiazolidinediones, α-glucosidase inhibitors, DPP-4 inhibitors and sodium-glucose cotransport protein 2 inhibitors, insulin, and GLP-1 receptor agonists.
1. Proinsulin secretagogues include sulfonylureas and nonsulfonylureas. The former include glibenclamide, gliclazide, and glimepiride, which are indicated for type 2 diabetes where controlled diet, exercise therapy, and weight reduction do not satisfactorily control blood glucose; the latter mainly include repaglinide and miglinide, which are mainly used to control postprandial hyperglycemia. 2. Metformin is the drug of choice for the treatment of diabetes in the clinic and also has a weight-lowering effect. It also has the effect of reducing body weight.3.Thiazolidinediones are mainly used in the clinic for pioglitazone, which refuses to improve insulin sensitization and is suitable for obese patients with type 2 diabetes.4.α-glucosidase inhibitors mainly include acarbose, voglibose and miglitol, which are suitable for patients with carbohydrates as the main food component or postprandial glucose star elevation.5.DPP-4 inhibitors include Saxagliptin, Ligliptin, Vigliptin, Sitagliptin, Alogliptin, etc. 6. SGLT-2 is a new type of hypoglycemic drug, mainly by promoting urinary glucose excretion, so as to achieve the purpose of lowering sugar, mainly Dagliflozin and Engliptin.
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