1. First of all, the diagnosis should be clarified, mainly by checking FT3, FT4, TSH and autoantibodies in blood to confirm the diagnosis. 2. Make sure that hyperthyroidism in women of childbearing age are not pregnant, and 131 iodine treatment is prohibited during pregnancy and lactation. 3. Prohibit foods and medications that affect thyroid uptake of 131I, such as iodine-containing foods (seafood), propylthioxypyrimethamine, etc. 4. Perform routine physical examination and routine laboratory tests (liver and kidney function, blood routine, electrocardiogram, etc.). 5. Perform measurement of thyroid 131 iodine absorption rate to estimate the absorption of thyroid gland, if the 131 iodine absorption rate is too low, then it is not appropriate to treat it now. 6. Correct estimation of thyroid weight can be done by thyroid ECT imaging or ultrasonography. 7.For severe hyperthyroidism, symptomatic treatment should be given first according to the condition, such as anti-heart failure, anti-infection, leukocyte boosting, liver protection treatment or adjuvant treatment with beta-blockers and sedatives, vitamin and potassium supplementation. Some need short-term anti-thyroid medication and 131I treatment after the symptoms of hyperthyroidism are relieved to prevent inducing thyroid crisis.