Hormone therapy for patients with ulcerative colitis is a very common and effective approach, but it is not applied in all patients. The side effects are relatively manageable when hormones are applied in the short term, but if they are applied for a long time they must be applied under the guidance of an experienced doctor and not abused blindly. Hormones have side effects not only for patients with ulcerative colitis, but for all people. The side effects are as follows: 1. redistribution of fat, resulting in full moon face, the patient’s face is very complete like a round moon, buffalo back patients have a particularly wide back and very slender limbs, large stomach, acne, abnormal hair, osteoporosis: patients are prone to fractures; 2. if the patient himself has abnormal blood sugar metabolism, long-term application of hormones will also induce diabetes; 3. reduce the body’s Immunity, bringing about infections, including very rare infections, viral infections and other complications; 4, the emergence of water and sodium retention, inducing hypertensive edema situation, weight change.