The duplication of the long arm of chromosome 13 does not necessarily result in syndactyly, but it may cause fetal malformations, miscarriages, and cessation of embryonic development. The long arm of chromosome 13 is duplicated, called trisomy 13, and affected children are prone to miscarriage or death during the embryonic period, and even at birth they are prone to a variety of malformations. Craniofacial malformations include a small head, defective forebrain development, small eyes, and a wide, flat nose, often accompanied by mental retardation, and syndactyly may also occur. So there is a duplication of the long arm of chromosome 13, in which case further investigations are recommended. 4D ultrasound requires termination of pregnancy if fetal anomalies are detected with structural aspects of malformations.
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