Severe fatty liver can cause high estradiol and mild fatty liver can be without high estradiol. Estrogen is usually inactivated in the liver and converted to androgen. With severe fatty liver and abnormal liver function, estrogen inactivation is reduced, and estrogen in the blood will increase, resulting in high estradiol, but mild fatty liver without liver function damage usually does not have high estradiol. High estradiol can also be seen in other liver diseases, such as viral hepatitis, drug-induced liver injury, cirrhosis, etc. It can also be seen in female precocious puberty, ovarian endocrine tumors, pituitary tumors and other diseases, as well as in pregnancy, when taking drugs such as mifepristone. Patients with fatty liver or people with high estradiol should go to the hospital for treatment under the guidance of a doctor.