High blood uric acid may be caused by excessive production of uric acid and reduced excretion of uric acid. 1. Excessive production of uric acid: patients eat too much animal offal, seafood, broth and other high-purine diets, drinking beer, wine and other alcoholic beverages or high-sugar diets can lead to excessive production of uric acid in the body, which in turn causes high blood uric acid concentration. Leukemia, malignant tumor cytotoxic drugs after chemotherapy, hemolysis, rhabdomyolysis, severe epilepsy seizures, myocardial infarction, acute respiratory failure and other diseases can lead to an increase in the production of uric acid, resulting in elevated blood uric acid. 2. Reduced excretion of uric acid: uric acid is mainly excreted by the kidneys, renal tubular disease, renal insufficiency and other renal diseases can lead to uric acid excretion disorder and cause high blood uric acid concentration. Pyrazinamide, rifampicin, furosemide, low-dose aspirin and other drugs can also affect uric acid excretion. Alcohol can both increase uric acid production and decrease uric acid excretion. High blood uric acid may also be caused by other reasons, it is recommended that the patient to the regular hospital to further clarify the cause, and follow the doctor’s instructions for treatment.