Breast milk is the most ideal natural food for infants, containing all the nutrients and a variety of immunologically active substances needed for infant growth and development from 4 to 6 months, and is suitable for digestion and absorption by the infant’s gut. Since the infectiousness of hepatitis B virus is related to the infection status of the virus, whether a mother with hepatitis B virus can breastfeed varies according to the infection status of hepatitis B virus. The incidence and severity of common diseases in breastfed infants are significantly lower than in artificially fed infants because of the many nutrients and antiviral substances in breast milk after the newborn is given hepatitis B vaccine and high potency hepatitis B immunoglobulin. Therefore, breastfeeding should be encouraged for mothers with inactive replication of hepatitis B virus. Second, active viral replication, positive serum e antigen and HBV DNA, although mother-to-child transmission of hepatitis B virus is mainly through intrauterine placental infection or blood transmission during delivery, hepatitis B breastfeeding increases the rate of hepatitis B virus infection in infants also lacks clinical evidence, but hepatitis B surface antigen or hepatitis B virus DNA can be detected in the milk of mothers with active hepatitis B virus replication, I personally believe that breastfeeding is potentially dangerous . Of course, hepatitis B virus replication is not an absolute contraindication to breastfeeding. The key preventive measure is vaccination with hepatitis B vaccine combined with hepatitis B highly potent immunoglobulin at birth. Since vertical mother-to-child transmission is an important reason for the high rate of hepatitis B infection in China, strengthening protection is the key to the prevention and treatment of chronic hepatitis B. Vertical transmission of hepatitis B from mother to child occurs mainly during natural childbirth, and obstetric compression is a key way for the mother’s blood, amniotic fluid, and vaginal secretions to infect the baby. Therefore, it is best for mothers with active hepatitis B virus replication to avoid natural childbirth and for newborns to receive hepatitis B vaccine and high potency hepatitis B immunoglobulin as soon as possible, the sooner the better. Because hepatitis B immunoglobulin is the surface antibody to the hepatitis B virus, when injected into the infant, the antibody neutralizes the virus and provides immediate protection if the infant is infected. Hepatitis B virus is mainly transmitted through broken skin and mucous membranes into the blood, not through the digestive tract, but the human oral mucosa, including the gum mucosa is more easily broken, if there is hepatitis B infection blood into easy infection, therefore, hepatitis B virus active replication mothers try to avoid mouth-to-mouth feeding babies to cut off the possibility of mother-to-child transmission. Daily contact such as hugging and touching will not transmit the hepatitis B virus, and it is not necessary to take absolute isolation just because you are a hepatitis B mother.