Atrial fibrillation leading to cardiac arrest warrants immediate cardiopulmonary resuscitation (CPR), as well as treatment of post-resuscitation syndrome. 1. Cardiopulmonary resuscitation: (1) Basic life support: Immediate chest compressions, opening the airway and artificial respiration for the patient in cardiac arrest. Chest compression is to cross the hands to press the middle and lower part of the patient’s sternum, the depth of each compression is at least 5cm, and after the compression, lift up the arms to make the thorax completely rebound, and press the chest at a frequency of 100~120 times/min, and after 30 times of continuous pressing, open the airway, and immediately carry out artificial respiration for 2 times. (2) Advanced life support: on the basis of basic life, apply assistive devices and special techniques to establish more effective ventilation and blood circulation. 2. Treatment of post-resuscitation syndrome: such as the use of drugs such as niclosamide and lobeline to stimulate respiration under the guidance of doctors, adrenaline to raise blood pressure, and atropine to increase heart rate. Pay attention to monitoring the changes of the patient’s vital signs during the use of drugs. It should be noted that after the condition is stabilized, standardized treatment of atrial fibrillation should be carried out under the guidance of doctors, such as the use of amiodarone, rivaroxaban and other drugs to control rhythm and prevent stroke, and radiofrequency ablation of atrial fibrillation if necessary, so as not to cause serious consequences.