Intrahepatic cholestasis during pregnancy is a unique complication of pregnancy with a high incidence in Chile, Sweden and the Yangtze River basin in China. The exact cause of the disease is not known and may be related to female hormonal, genetic and environmental factors. Intrahepatic cholestasis during pregnancy occurs in late pregnancy, twin pregnancies, ovarian hyperstimulation and previous use of oral contraceptives, where estrogen is at a high level, which can eventually lead to impaired bile acid metabolism and bile outflow, resulting in cholestasis. If there are women in the family such as mothers or sisters who have suffered from the disease, it will increase their own prevalence. The higher prevalence in Chile, Sweden and the Yangtze River basin in China suggests that the occurrence of the disease is related to genetic factors, and there are obvious racial differences, regional distribution and family aggregation. In addition, the occurrence of the disease is seasonally related, with a higher incidence in winter than in summer. After suffering from intrahepatic cholestasis during pregnancy, pregnant women mainly present with itchy skin, skin scratching, and jaundice. When pregnant women have significant steatorrhea, it can lead to abnormal coagulation and postpartum hemorrhage; excessive bile acids have toxic effects and can lead to fetal distress, preterm delivery, amniotic fluid placenta fetal fecal contamination, and even unpredictable sudden fetal death and intracranial hemorrhage in newborns.