Avascular Necrosis of the Femoral Head (ANFH) is a progressive pathological process of ischemia, necrosis, and collapse of the femoral head due to a variety of different causes that block blood flow to the femoral head. ANFH has many causes and causes a large number of patients to lose joint function; ANFH often involves both femoral heads, and although ANFH can be treated conservatively or surgically, no single treatment method has been shown to be very effective. Therefore, timely diagnosis and treatment in the early stages of ANFH lesions is very important. Is head-preserving treatment possible? The answer is yes, the key is to have good indications and apply effective drugs. Current studies have demonstrated the efficacy of diphosphonates, such as alendronate, in the treatment of femoral head necrosis. Agarwala first reported on the efficacy of the diphosphonate compound, alendronate sodium, in the treatment of ANFH. Not only did alendronate improve the symptoms of ANFH, but it also slowed the progression of ANFH and reduced the risk of femoral head collapse. Other studies have shown the same results, and diphosphates are now considered to be the standard of care for ANFH.