Diabetic lower limbs and face edema may be caused by diabetic nephropathy due to kidney injury resulting in edema, at this time, dietary treatment, control of blood glucose and blood pressure, regulating blood lipids treatment and so on. Diabetic nephropathy is one of the common complications in diabetic patients, which can be confirmed by renal puncture biopsy. Kidney damage is commonly is the lower extremities and face and other loose tissue edema manifestation, so often choose to target diabetic nephropathy treatment. The treatment of diabetic nephropathy includes dietary treatment (limiting protein intake), blood sugar control treatment (metformin, acarbose or insulin injection, etc.), blood pressure control treatment (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, etc.), lipid regulation treatment (statins, etc.) and other treatments. The above medications need to be administered under the guidance of a medical professional. There may also be other causes of lower limb and face edema in diabetic patients, it is recommended to consult a doctor in time to clarify the cause of the disease and then symptomatic treatment.