Why do I need a kidney puncture biopsy for nephrotic syndrome? Because nephrotic syndrome is not a disease, but a group of diseases with similar clinical manifestations. And the use of renal biopsy is beneficial to clarify the diagnosis, guide the treatment, judge the prognosis, explore the relationship between clinical typing and pathological typing, and is also the main method to improve the clinical treatment of nephrotic disease. 1, clear diagnosis: At present, there are basically 2 diagnostic methods for kidney disease, one is clinical diagnosis and the other is immunopathological diagnosis, and the two are applied in combination to make a clear diagnosis, so we must rely on renal puncture biopsy. For example, the clinical manifestation is nephrotic syndrome, but pathologically it is seen in a variety of lesion types, such as microscopic lesions, podocytosis, IgA nephropathy, membranous nephropathy, focal segmental glomerulosclerosis, etc., and the final diagnosis must rely on immunopathological diagnosis. Some other rare diseases, such as amyloidosis, lipoprotein nephropathy, are also clinically manifested as nephrotic syndrome, which cannot be diagnosed clinically without biopsy. 2.Guiding treatment: After the diagnosis is clear through renal puncture biopsy, it can provide an important basis for clinical development of treatment plan and revision of treatment plan. If the diagnosis of renal puncture biopsy is micro lesion type, the application of hormone therapy is good, while other pathological types, the responsiveness to hormone therapy is also different, then cytotoxic drugs may be added early to avoid delaying the disease. 3.Judging the prognosis: After the clear diagnosis of renal puncture biopsy, the prognosis of the lesion can be basically estimated. The prognosis of the same type of nephropathy diagnosed clinically is not the same as the pathological manifestation.