Infants are defined as less than one year old, fat grain on the face, generally do not need special treatment, accompanied by inflammation and infection, can be given topical drug treatment as appropriate. Fat grains on the face of infants, generally does not affect the health, it is recommended to closely observe, with the baby’s age, pay attention to facial cleansing, generally can be relieved on their own. Fatty grains on the face of babies during the neonatal period may also be considered as neonatal acne. Babies get too much androgen from their mothers during the fetal period, and after birth, maternal androgen may cause stimulation to the sebaceous glands, leading to sebaceous gland hyperplasia. If drainage is blocked, acne may form. This condition does not require special treatment and may resolve on its own. If improper care induces bacterial infection, it is recommended to give topical antibiotic drugs to apply under doctor’s supervision. To summarize, fat grains on the face of infants are recommended to be closely observed and well cared for, and most of them can subside on their own with time. If there is any other discomfort, go to the neonatology department or dermatology department of the hospital for consultation and treatment if necessary.