Duloxetine can be used to treat OCD, but it is generally effective. This medication is currently in the third line of medications used to treat OCD. The first-line drugs for OCD are the following four, namely sertraline, fluoxetine, paroxetine, and fluvoxamine. There are three second-line drugs, the first is clomipramine, the other two are citalopram and escitalopram, but citalopram and escitalopram are not approved by the Chinese Food and Drug Administration, so these two drugs are generally not available in China, and duloxetine belongs to the third-line drugs. Therefore, if you want to treat OCD, you must follow the arrangement of medical advice to take medication, and it is better to choose the first-line and second-line medication.