The liver is the largest gland in the human body and an important chemical plant in the human body. Since it receives blood supply from both the hepatic artery and portal vein, especially the blood from the digestive system such as the digestive tract flows back to the liver through the portal vein, the liver has a very rich blood flow, which makes it a common metastatic organ for cancer. The most important characteristic of cancer is that the cells are uncontrolled and grow indefinitely, and can be transferred to neighboring tissues or distant organs and tissues through direct infiltration, lymphatic metastasis, implantation metastasis and hematogenous metastasis, etc. According to statistics, about 30% of malignant tumors can be metastasized to the liver. It is estimated that about 30% of malignant tumors can metastasize to the liver through direct lymphatic metastasis, implantation metastasis and hematogenous metastasis, and it is called metastatic liver cancer (also called secondary liver cancer) to distinguish it from primary liver cancer. Metastatic liver cancer can be detected by ultrasound, CT, MRI, and can be further confirmed by percutaneous liver aspiration. Metastatic liver cancer AFP (alpha-fetoprotein) is usually not elevated, while primary liver cancer AFP is elevated. So what are the sites of tumors that are prone to metastasis to the liver? Since the liver mainly recycles blood from the gastrointestinal tract, the most common tumors that metastasize to the liver are gastrointestinal tract tumors: gallbladder cancer, colorectal cancer, stomach cancer and pancreatic cancer in that order. In addition, breast cancer, ovarian cancer, melanoma, lung cancer, and esophageal cancer also metastasize to the liver. More than 50% of colon and rectal cancer patients have metastases to the liver. Indeed, if the primary cancer lesion has metastasized to the liver, it means that the primary cancer is already in advanced stage. Since metastatic liver cancer is in advanced stage, is it hopeless? Not necessarily! Here we report two cases of patients to illustrate. Case 1: Patient, male, 55 years old. He was admitted to the hospital with intestinal obstruction because of progressive wasting for two months, no gas and no bowel movement for 3 days. The post-admission CT showed an occupancy in the sigmoid colon, which grew around the intestinal lumen and caused sigmoid obstruction. The diagnosis was sigmoid colon cancer with intestinal obstruction. However, at the same time, an occupancy in the right lobe of the liver was found to be about 5 cm in size, which was diagnosed as liver metastasis of sigmoid colon cancer. Due to intestinal obstruction, the patient underwent emergency sigmoid colectomy (including tumor). One month later, he was treated with chemotherapy and liver intervention, p53 and hepatic artery embolization, and the liver metastasis was significantly reduced to 3 cm. Another month later, he underwent partial hepatectomy (including metastasis), and his recovery was smooth, and no recurrence has been seen for more than 5 years. Case 2: Patient, female, 61 years old. She came to the hospital with blood and mucus in the stool and anemia for three months, which she thought was “dysentery” and took two or three kinds of drugs with little effect. After admission, he was diagnosed with ascending colon cancer by colonoscopy and a metastasis in the left outer lobe of the liver, about 4 cm in size, by enhanced CT of the liver, and a standard radical right hemicolectomy was performed first. He recovered well after surgery, and after two courses of chemotherapy, he underwent resection of the left outer lobe of the liver (including metastases). It has also been more than 5 years since then without any further recurrence. Therefore, metastatic liver cancer is not untreatable. For patients with metastatic liver cancer who have resected the primary lesion, especially those with single metastatic lesion in the liver, systemic chemotherapy, arterial chemoembolization (TACE), anhydrous alcohol injection, p53 and other immunobiologic therapies can be used to reduce the size of metastatic foci in the liver and survive with cancer, or partial hepatectomy can be performed for a limited period to remove the metastatic foci. Currently, surgical resection of part of the liver and radiofrequency ablation therapy are the most effective methods to treat metastatic liver cancer. These treatments alone or in combination are the key to cure or prolong the life of patients. Therefore, for patients with liver metastases from cancer, both doctors and patients should adopt a positive attitude towards the treatment of liver metastases, especially patients should have a positive and optimistic attitude, face it rationally and actively cooperate with doctors’ treatment. Cancer liver metastasis is not terrible! More than that, it is not the end of patients.