Liquid nitrogen cryotherapy for plantar warts works. Plantar warts are a type of common warts, a benign skin lesion caused by human papilloma virus infection of the skin mucosa. It is a benign lesion of the skin caused by the infection of the mucous membrane by the human papilloma virus. It begins as a small, shiny papule on the sole of the foot, and forms a brownish-yellow, rough and thickened patch when it is pressed. Liquid nitrogen freezing is the most commonly used physical therapy, through the low temperature to make the tissue cells dehydrated and damaged necrosis, and then make the warts fall off. Liquid nitrogen freezing is convenient, fast and inexpensive, but the course of treatment is longer, usually need 4~6 weeks until the warts completely off. After freezing, the local blisters will be formed, hindering daily walking, and the surrounding normal tissue is inevitably damaged, and may also recur.