Recently, a microblog titled “Don’t squeeze too much toothpaste” has attracted the attention of many netizens. The microblog mentioned that sodium lauryl sulfate, a chemical widely used in toothpaste, may cause gastrointestinal disease and liver toxicity, making the mouth prone to ulceration, and that the abrasive agents in toothpaste are also thought to harm the gums. Among the dentistry patients I see, I have not found anyone who has directly or indirectly caused oral cancer because of too much toothpaste, nor have I heard my colleagues talk about similar cases, but improper use of toothpaste can indeed be detrimental to oral health. Toothpaste is made up of powdered rubbing agents, wetting agents, surfactants, binders, flavors, sweeteners and other special ingredients. The sodium lauryl sulfate mentioned in the above microblog is an anionic surfactant that is often used as a foaming agent for toothpaste. Generally speaking, very little of these substances are absorbed into the body when brushing the teeth, and there is little impact on health after rinsing the mouth. Toothpaste should not be squeezed too much, generally the amount of soybean is large enough to clean the mouth of adults. For babies using children’s toothpaste, an amount the size of a green bean is also sufficient to clean the mouth. It should be noted that children under the age of 3 should not use fluoride toothpaste. Because children are prone to swallow toothpaste during brushing, fluoride toothpaste has certain health hazards.