Whether you can apply anthralin to itchy soles depends on the situation, and the prerequisite for using anthralin is that the skin is not damaged. If the skin is broken, the use of anthralin may cause redness and swelling in the broken area, which may be counterproductive. Itching may be caused by a fungal infection. It is important to go to a regular local hospital and apply antifungal ointment under the guidance of a doctor, rather than using it privately.