When there is a blood clot in the foot, treatment should be carried out according to the nature of the blood clot in the foot. If it is just a plaque, this situation should be selected according to whether it is a stable plaque or an unstable plaque, as follows: 1. Stable plaque: it causes heavy stenosis and ischemia of blood vessels, which requires endovascular treatment and intervention with stenting or endothelial debridement to improve and remove thrombosis; 2. Unstable plaque: it is a soft plaque, which can also change, and can be treated with statin drugs, mainly atorvastatin and rasulvastatin. Statin and Rosuvastatin can stabilize the plaque through statin drugs. At the same time, anticoagulant drugs should be given according to the severity of ischemia, and the effect of anticoagulant drugs is similar to that of old warfarin and new anticoagulant drugs. Endovascular treatment and anticoagulant drugs can effectively improve the symptoms by assessing the thrombosis of the lower limbs.