Warts are caused by human papillomavirus (HPV) infection, which tends to invade the epidermis, especially the extremities such as the hands and feet, and often involves the external genitalia, rectum, mouth, throat and other mucous membrane areas. Individual types of HPV are associated with cancer and should be given due attention. Warts can be transmitted, and are generally more easily transmitted by extrusion and injury of mucous membranes and skin. The incubation period is unclear and is estimated to be from a few weeks to as long as 1 year. When choosing a treatment plan for warts, the doctor’s first consideration is to not have distressing side effects, and sometimes the best treatment is to leave them alone. Common side effects include: crusting (laser, microwave, liquid nitrogen freezing, caustic acid, zebular acid); blistering (liquid nitrogen, microwave, zebular acid, 5-FU, bleomycin); allergy (zebular acid, chemotherapy, retinoic acid, glutaraldehyde); and long-term hypopigmentation or hyperpigmentation (liquid nitrogen, 5-FU). Warts cannot be completely cured by a single treatment alone. The treatment should be determined by the location, age, duration, external manifestations and characteristics of the warts. The face: often flat warts, can be treated with retinoids, but also appropriate choice of 5-FU and spotted acid. The actual nitrogen freezing should be carefully chosen as it can cause hyperpigmentation and hypopigmentation. The skin may be treated with a combination of caustic acid, liquid nitrogen, microwave, and 5-FU. bleomycin may be used in difficult to control cases. The rash is thick and can be treated with a combination of retinoic acid, antiviral, and immune modulation systems. Finger and toenail: perineal warts can be treated with 5-FU, caustic acid, and zebular acid. Liquid nitrogen or microwaves are effective in the treatment of common warts, but caution should be exercised here because it causes pain that can deform the finger and toenails. Vulvar mucosa: Causes warts, a sexually transmitted disease. Topical application of zebular acid, 5-FU, onychomycin, and imiquimod cream is available. Laser or liquid nitrogen freezing are also good options. The latest use of photodynamic therapy has good efficacy, high eradication rate, and few side effects, but it is more expensive. The above methods can be used in combination. Children: salicylic acid, zebular acid, and liquid nitrogen are effective. Recently, pansentine and cimetidine have been reported to be effective in the treatment of multiple common warts in children.