There are many reasons why IVF is not successful, such as the quality of the patient’s eggs, their age, and how their physical condition may affect it. On the other hand, the quality of the patient’s sperm can also have an effect, but not a big one. On the other hand, the technology used by the medical institution to carry out IVF also has a great impact on the success rate. In other words, when doing IVF, all aspects are very important and can affect the success rate of IVF children. The patient should actively cooperate with the doctor, and the more the doctor knows about the patient, the better the chances of success. “IVF” technology is rapidly developing and the success rate is increasing. We hope that every patient who needs IVF can realize their dream of becoming a mother. The first major factor: age Age is an important factor in the success of IVF technology, domestic and foreign literature reports that the age of 25-34 years old has the highest success rate, up to 45%, after ≥ 35 years old the success rate is 26%-30%, > 35 years old the success rate will decline, > 40 years old the success rate is about 20%, and the live birth rate decreased significantly, and the impact on eugenics is also greater. When over 45 years old, IVF treatment cannot be done with one’s own eggs because the success rate is extremely low and the chromosomes of the embryos are prone to abnormalities. the miscarriage rate in IVF treatment increases greatly in the older age group, and the preterm births and stillbirths are also higher than in younger pregnant women. The second major factor: the cause of infertility in patients older primary infertility, patients with severe endometriosis and polycystic ovary syndrome with uterine abnormalities, patients who do not get sperm from the testes of patients with severe oligospermia or azoospermia, or those who have a large number of abnormal sperm, and those with abnormal eggs or abnormal development, etc., also have a higher failure rate in IVF treatment. The third major factor: chromosomes In some couples with primary infertility or a history of bad pregnancies, there are some couples with normal variant of chromosomes. These couples with chromosomal problems can conceive through IVF technology, but the failure rate and miscarriage rate are higher. The fourth major factor: the intrauterine environment The endometrium is the most important site for embryo implantation causing damage to the endometrium, myometriosis, endometritis, endometrial polyps or other lesions of the endometrium may cause the embryo to fail to implant and affect the success rate. New research has found that the endometrium secretes a special sugar molecule, and when this sugar molecule is lacking, the conception rate is greatly reduced. It is believed that in the near future, medical doctors will overcome this problem and improve the pregnancy success rate. The fifth factor: excellent embryo rate When there is a problem with sperm and egg, no fertilization or fertilization without oogenesis cannot complete embryo transfer, excellent embryo is an important condition for success. According to the six levels of embryo grading: fresh embryos of grade I-IV are available for transfer, and grade I. II are excellent embryos. At present, excellent embryos are only morphologically classified and the potential of embryos is not known. Now, embryology chilblains are working on a more advanced method of embryo assessment, which hopefully will predict the probability of conception of embryo eagles. However, excellent embryos also require a good uterine environment, good endocrine conditions, and the physician’s superior embryo transfer technique. Couples of normal reproductive age who have intercourse for 1 month according to the time of draining have only about 20% chance of pregnancy. So we hope to have a good state of mind during the treatment, which is also an important factor for success. The sixth factor: psychological state Many data show that the psychological and mental state of the patient is an important factor that affects the success or failure of IVF treatment. There are many experts abroad who use psychological test scales to do psychological assessments of couples undergoing IVF treatment. The assessment was compared with the group. The results of the study found that the group that had received psychological treatment to relieve stress had a conception rate almost one time worse than the group that had not undergone psychological treatment, even though the age, education level, cause of infertility, treatment plan, amount of medication, and embryo quality were basically the same. Experts believe that women with high psychological stress have their endocrine secretion affected, their blood vessels are in a state of long-term contraction, which affects the local blood flow to the uterus and ovaries, and the tension in the nervous system causes abnormalities in the release of some neuromediators, resulting in disorders in the contraction of the muscles of the uterus and fallopian tubes, causing the embryo to fail to implant and leading to treatment failure. Therefore, it is very important to relieve the psychological stress, communicate between the doctor and the patient, and have mutual understanding and encouragement between the couple.