The treatment methods of leg artery thrombosis mainly include medication, surgery, intervention and so on. 1. Drug treatment: leg artery thrombosis causes leg coldness, pain, numbness, etc., patients can use leg anticoagulant drug treatment, the drug is generally aimed at the thrombus of small arteries of the leg, the common clinical drugs include warfarin, rivaroxaban, etc.; can also be such as streptokinase, urokinase and other drugs to carry out thrombolytic therapy. 2. Surgery: For acute thrombosis of leg arteries, arterial thrombectomy should be carried out for treatment. There are two methods of surgical treatment: one is to cut open the artery and remove the thrombus directly; the other is to use Fogarty catheter balloon to remove the thrombus. If there is localized gangrene in the lower limbs, amputation may be required. 3. Interventional therapy: Interventional therapy requires vascular puncture in the leg, and at the same time, catheterized thrombus extraction and thrombolytic therapy are carried out, so that thrombus in the leg can be eliminated to achieve the therapeutic purpose. When thrombosis occurs in the leg artery, it is necessary to go to the regular hospital for treatment in time and follow the doctor’s advice to avoid aggravation of the condition. Medications should be applied under the guidance of a doctor.