Autoimmune pancreatitis does not usually produce cancer. Pancreatic cancer is a malignant tumor of the digestive tract with insidious onset, rapid progression, very poor therapeutic effect and prognosis, and its incidence rate has been on the rise worldwide. The etiology of pancreatic cancer is not yet clear, and its high-risk factors mainly include long-term smoking, obesity, long-term heavy drinking, chronic pancreatitis, diabetes mellitus, long-term exposure to chemical substances, high-fat and high-protein diets, and heredity. Currently, domestic guidelines also point out that the risk factors associated with the development of pancreatic cancer include obesity, type 2 diabetes and smoking, etc. 5% to 10% of pancreatic cancer patients have genetic susceptibility factors. Patients with chronic pancreatitis have the possibility of malignant transformation, usually familial pancreatic cancer patients. Clinically, the cause of autoimmune pancreatitis is not very clear, but it is thought to be related to autoimmunity and easily confused with malignant tumors, but it is a benign disease, most of which will not be cancerous. In conclusion, there are many risk factors for developing pancreatic cancer, and autoimmune pancreatitis is usually not cancerous. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for a comprehensive assessment of the condition and follow the doctor’s instructions to avoid delaying the condition.