Chest tightness the day after drinking may be caused by gastrointestinal irritation, lung infection and coronary heart disease. 1. Gastrointestinal irritation: alcohol can cause irritation to the esophagus and stomach, which can lead to mucosal congestion, abnormal secretion of digestive juices, and even ulcers, resulting in symptoms of chest pain the day after drinking. 2. Lung infection: after drinking a lot of alcohol and getting drunk, it is easy to vomit and inhale, leading to bronchial obstruction, which may lead to lung infection. When the lungs are infected, there may be chest tightness the day after drinking, usually accompanied by coughing, coughing up sputum, fever and other symptoms. 3. Coronary heart disease: when the patient already exists cardiovascular disease, alcohol will cause coronary artery spasm contraction and aggravate the ischemia of the heart, thus appearing the next day after drinking chest tightness. It is recommended to drink less or no alcohol in life, and if you have cardiovascular and cerebrovascular diseases, it is recommended to quit smoking and drinking, and if you have any discomfort after drinking, you should go to the hospital immediately.