Diabetic lower limb pain may be caused by vasculopathy or peripheral neuropathy, which should be treated with medications to control blood sugar, nourish nerves, improve circulation, and relieve pain under the guidance of a doctor, and surgery should be considered in severe cases. If diabetic patients with lower limb pain, mainly for the treatment of the original disease, need to standardize the application of hypoglycemic drugs to control blood sugar levels, such as metformin hydrochloride tablets. For diabetic lower limb pain, drugs that nourish the nerves, improve circulation, and relieve pain should be applied according to the doctor’s instructions, such as methylcobalamin tablets, prostaglandin, pregabalin, gabapentin and so on. If diabetic patients have lower limb blood vessel stenosis or blockage, etc., which causes lower limb pain, surgical intervention may have to be considered to improve blood circulation and reduce or eliminate pain. Diabetic patients with lower limb pain must be taken seriously and go to the hospital as soon as possible to avoid aggravation of their condition.