Since the application of biological agents, their efficacy and rapid onset of action have undoubtedly been a boon to patients with rheumatoid arthritis and ankylosing spondylitis. However, the high price of these agents has made it difficult for many patients to get them and for doctors to recommend them to their patients. Many colleagues asked me about the price of biological agents in Japan, and at that time I was studying at the Yamaguchi Medical Research Center, and in my spare time I also compared the price of drugs in my country with each other, and at that time I was most impressed by Colapitol, because it was the original Japanese product, and it was simply a cabbage price. Today on the Internet to download out, for conversion. Shandong Province Qianfo Mountain Hospital Rheumatology and Immunology Department Wang Zhankui biological uのレミゲ`ド (Infosynthesis interest monoclonal antibody, 100mg/branch) 100,285 shake エンブレル (to Cypress, 25mg/branch) 15501 shake ヒュミラ (Adalimum, 40mg/branch) 71,097 shake アクテムラ (Dezhu monoclonal antibody) 200ml 59,380 shake オレンシア (Abaship 53,467 shake with 100 yen / 7 yuan RMB conversion: Infosol monoclonal antibody, 100mg/stem: 7,000 yuan Isaac, 25mg/stem 1,000 yuan Adalimum, 40mg/stem 5,000 yuan The latter two are not often used in China, so they are not converted. And domestic prices are basically comparable. But according to the monthly income conversion, we are too disadvantaged. According to the average of Jinan people 3000 yuan per month, the lowest income of doctors in Japan trainee doctors 320,000 yen per month. Infosys interest monotherapy: 800,000 yen / 1.12 million (first 3.5 months); 56,000 RMB / 10,000 RMB. Esaote (per month): 120,000 yen/320,000; 8,000 RMB/3000; Adalimumab: 140,000 yen/320,000; 10,000 RMB/3000; Conclusion: The prices of drugs from multinational companies that are in line with international standards seem to be slightly cheaper to import into the country, and there is no excuse for that. But by income, our patients are simply in deep water.