Cirrhosis and diabetes mellitus both affect life expectancy if not treated in time. The most common cause of cirrhosis is hepatitis B virus infection, if pay attention to nutrition, taking anti-hepatitis B virus drugs such as entecavir to reduce the viral load in the body, it can control the disease process of cirrhosis patients, patients will get long-term survival; if cirrhosis is not treated in time, it will cause upper gastrointestinal hemorrhage, nutritional disorders, malignant stroma and other serious manifestations, which can lead to short-term death of patients. Diabetes mellitus can be well controlled by the use of metformin, acarbose, insulin and other drugs to control the blood glucose level, so that the patient will obtain long-term survival; if diabetic patients do not take active treatment measures, it may be due to the elevation of blood glucose lead to ketoacidosis, hyperosmolar hyperglycemia syndrome and other serious complications, which can lead to the death of the patient in a short period of time. Therefore, patients with cirrhosis and diabetes should go to the hospital in time, and follow the doctor’s instructions to use medication to control the disease can be very good control of the disease, so that the patient can be able to live with the disease for a long time.