When varicose veins of saphenous combined with thrombus, the condition can be relieved by medication and surgery. 1. Drug treatment: patients can use anticoagulant drugs, such as warfarin, rivaroxaban, etc.; venous active drugs, such as diosmin, bicoumarin, etc.; non-steroidal anti-inflammatory drugs, such as aspirin, ibuprofen, etc. under the guidance of the doctor, in order to control the condition and avoid further aggravation of the lesion. If the thrombus is formed in the early stage, i.e. within 72 hours of its formation, the use of streptokinase, urokinase and other drugs can be considered for thrombolytic therapy. 2. Surgery: Usually, purely conservative treatment cannot completely resolve the thrombus of saphenous vein varicose vein, therefore, if the condition is stabilized, minimally invasive surgery or traditional surgery, such as laser coagulation, saphenous vein ligation with varicose vein stripping, can be used to avoid serious complications. After the operation, patients still need to follow the doctor’s instructions for local compression, such as wearing compression stockings, to avoid postoperative hematoma and oozing. It is recommended that patients strictly follow the doctor’s prescription of medication, actively cooperate with the doctor’s treatment, pay attention to rest in life, but also need to pay close attention to the physical condition, and be vigilant about the embolus dislodgement and the emergence of chest tightness, coughing, dyspnea and other phenomena of pulmonary embolism.