There is no precursor of diabetic nephropathy, but there will be some early clinical manifestations, which may include pale face, abnormal urine output, fatigue, swelling and other symptoms, and you should go to the hospital in time to have the relevant examination. 1. Pale face: when suffering from diabetic nephropathy, renal anemia will occur, which will cause pale face and poor mental health. 2. Abnormal urine volume: when suffering from diabetic nephropathy, there will be abnormal urinary protein, which will cause foamy urine or urine volume significantly increased or decreased. 3. Fatigue: When suffering from diabetic nephropathy, the metabolism of the body will be disturbed and the appetite will be decreased, which will lead to the phenomenon of general weakness and fatigue. 4. Swelling: When diabetic nephropathy occurs, a large amount of protein is discharged from the urine, which reduces the permeability of plasma, and at the same time, due to the abnormal discharge of water from the body, water is retained in the body, which leads to the phenomenon of swelling in the body. When the body appears uncomfortable symptoms, should go to the hospital in time for relevant examination, clear diagnosis, follow the doctor’s instructions for targeted treatment.