Patients with mild toxicity may not require any form of intervention and may also be treated with topical dexamethasone acetate ointment (dermapen), hydrocortisone ointment (1% or 2.5%) or clofentezine gel (10%) and erythromycin ointment. For dry skin with pruritus, thin phenol glycerin lotion (twice daily) or benadryl ointment may be applied to the pruritus. The dose of EGFRI should not be changed due to mild toxicity and should be reassessed after 2 weeks and treated as moderate toxicity if there is deterioration or no significant improvement. Moderate toxicity Use topical hydrocortisone ointment (2.5%) or erythromycin ointment and oral loratadine. For dry skin with itching, apply Benadryl ointment or compound benzoic acid ointment to the itchy area. For those with spontaneous symptoms, oral minocycline (memantine 100 mg Bid) should be given as soon as possible.
If the condition worsens or does not improve significantly, the patient should be treated as severely toxic. Interventions for severe rash are basically the same as for moderate rash, but the drug dose can be increased. If necessary, a shock dose of methylprednisolone (methylprednisolone) may be given, and the EGFRI dose may be reduced; in case of co-infection, an appropriate antimicrobial agent such as cefuroxime (250
If there is co-infection, choose the appropriate antimicrobial agent, such as cefuroxime (250 mg Bid). If adverse reactions do not resolve sufficiently after 2-4 weeks, consider suspending the drug or discontinuing treatment.