Chronic prostatitis (CP) is the most common urological disease that affects young and middle-aged men under 50 years old, with clinical manifestations such as painful symptoms, changes in urination, abnormal sexual function, and neuropsychiatric symptoms. “It is mostly caused by dampness and heat, stagnation of Qi and blood, and kidney deficiency. The chronic prostatitis/chronic pelvic pain syndrome (CPPS) belongs to type III of the NIH prostatitis classification (divided into type IIIa and IIIb), formerly known as non-bacterial prostatitis, is the most common type of CP, CPPS accounts for more than 90% of the total incidence of chronic prostatitis, its pathogenesis is still not well understood, clinical treatment lacks specificity, this article on the recent country about CPPS drug treatment. The pathogenesis of CPPS is still poorly understood and clinical treatment is not targeted. In the treatment of individualized principles, the main purpose of comprehensive treatment to relieve symptoms and improve the quality of life. Antibiotics, α-blockers, non-steroidal anti-inflammatory analgesics, botanicals, M-blockers and other drugs are often used for treatment. 1.1 alpha-adrenergic receptor blockers: Reflux of urine into the glandular ducts of the prostate can cause chemical prostatitis, which may be an important factor in causing CPPS. The results of the study showed that alpha-blockers can significantly relieve the symptoms of CPPS and have significant efficacy. It is a basic drug for the treatment of type III prostatitis because it can relax the smooth muscle in the prostate and bladder and improve the symptoms and pain in the lower urinary tract. These drugs include terazosin, napalmedil, doxazosin and tamsulosin. The results of the study showed that 2 patients were cured, 32 patients were effective and 55 patients were treated with nafipendil (25 mg/d) for 4 weeks. The total effective rate was 32.4%, and the total effective rate was 84.8%. Ye Jin [5] et al. used terazosin hydrochloride to treat 165 cases of chronic non-bacterial prostatitis in a course of 3-4 weeks. The result was an overall response rate of 80.61% with mild adverse effects and satisfactory efficacy. α-blocker drug side effects mainly include postural hypotension and ejaculatory disorders, so their side effects should be considered when selecting the drug. 1.2 Non-steroidal anti-inflammatory analgesics: are empirical drugs for the treatment of symptoms related to type III prostatitis, whose main purpose is to relieve pain and discomfort. For those with perineal discomfort, hidden pain and discomfort in urination, NSAIDs can be used. Commonly used NSAIDs are: ibuprofen, anti-inflammatory pain, fenpropathrin, celecoxib, etc. The analgesic effect of NSAIDs is achieved by inhibiting cyclooxygenase (COX) and blocking local prostaglandin synthesis, thus reducing the transmission of painful stimuli caused by these inflammatory mediators to the center and achieving analgesic effect. Yin Hang et al. showed that both specific cyclooxygenase-II (COX-2) inhibitors and α-blockers can reduce the expression of inflammatory factors in EPS, and the combination of drugs can improve the efficacy. 1.3 Botanicals: sernitone, Tonguling, and Prostat have certain therapeutic effects on chronic prostatitis. It is a pollen extract with anti-infection and anti-edema effects, and can relax the bladder forced urinary muscle and urethral smooth muscle, and has a relieving effect on perineal pain, lumbosacral pain, scrotal pain and urinary frequency and urgency. 1.4 M-blockers: have a relieving effect on patients with urinary frequency, urinary urgency and nocturia. In the case of type III prostatitis, 286 patients were selected by Jia Zhenyu and divided into 124 cases in the M-blocker treatment group (trospium tartrate tablets) and 78 cases in the non-steroidal anti-inflammatory analgesic (indomethacin tablets) treatment group, and quinolone antibiotics or sulfonamides were randomly selected as adjuvant therapy, while the control group was treated with levofloxacin alone. The NIH-CPSI score before and after treatment was used as the index of efficacy evaluation. The effective rate of the treatment group was 70.97% in the post-treatment alcoholic acid trospium tablets. The efficiency rate of indomethacin tablet treatment group was 41.03%. The effective rate of levofloxacin control group was 36.9%. The difference between the treatment group of Trospium tartrate tablets and the other two groups was statistically significant, indicating that M-blockers can well relieve the symptoms of prostatitis. 1.5 Antibiotics: The use of antibiotics for the treatment of CPPS is controversial and opinions are not uniform, usually for type IIIa patients, considering the uncertainty of lower urinary tract pathogens examination and the presence of inflammation in the prostatic fluid, clinical antibiotics can be tried for a short period of time for these patients, and if they are not effective, they do not need to be continued. Type IIIb:Antibiotic treatment is not recommended. 1.6 Combined drug therapy CPPS etiology is complex, single therapy is often difficult to achieve satisfactory results, the clinical common use of integrated treatment. Ye Zhangqun et al. conducted a double-blind, parallel-controlled and multicenter study, which confirmed that the combination of sernitone and antibiotics regimen could more effectively relieve the symptoms of CPPS patients with good tolerability, which is worth promoting in the clinical application. In a multicenter study, the combination of chenidon and antibiotics was found to be more effective in relieving the symptoms of CPPS patients and was well tolerated. The results showed that most patients had significant improvement in symptoms. Kong Liangqi et al. used the combination therapy of doxazosin controlled-release tablets (4 mg/d,), celecoxib (200 mg/d), and sertraline (50 mg/d) in 57 patients with CP/CPPS for a course of 3 months. The patients were scored on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) before, 4, 8 and 12 weeks after treatment and adverse effects were recorded. The results showed 31 cases of significant effect and 18 cases of effective effect, with an overall effective rate of 92% (49/53). The combination regimen of a-blockers, COX-2 inhibitors and antidepressants was considered safe and effective, and could significantly alleviate the clinical symptoms of CP/CPPS patients. Lu Kai et al. treated 68 patients diagnosed with NBP with the combination of Harlequin and anti-inflammatory pain suppositories, and the total effective rate of treatment reached 87%, and there was a statistically significant difference in the scores of various prostate symptoms before and after treatment; the combination treatment for NBP was safe and effective. 2, Chinese medicine clinical treatment of CPPS with Chinese medicine using the treatment of clearing damp heat, activating blood circulation, removing blood stasis, tonifying the kidneys and other treatment methods. The clinical effect is relatively satisfactory and has the advantage of safety. Chen Yi [15] randomly divided 144 patients into 2 groups. 76 patients in the treatment group were given Tiger stick clearing soup (empirical formula): Tiger stick, Tu Fu Ling, Yin Hua, Fructus septicum, White flowered snake’s tongue herb, Half lotus, Orange kernel, Tai Wu, Chuan Niu Kne, Dioscorea Z, Wang Bu Liu Xing, Xiao Fei Xiang, Shi Calamus, Raw licorice. If the symptoms of urinary tract are obvious, add Che Qian Zi, Dandelion and Chuan Mu Tong; if the symptoms of pain are obvious, add Yan Hu Suo, Chuan Neem and Lactation; if the sexual function is reduced, add Xian Mao, Xian Ling Spleen and Serpentine; if the symptoms of neurasthenia are obvious, add Sheng Long Mu, Yuan Zhi and Nightshade; if the prostate gland is nodular, add San Ling, Curcuma and Andrographis. In the control group, 68 cases were given terazosin capsules orally, 2 mg each time, once/day. The treatment lasted for 4 weeks. The effective rate of the treatment group was 90.8%. The control group was 73.5%. Wang Xiaozhi used a randomized, controlled clinical research method, the test group was given prostate Antone tablets, and the control group was given Pulaoan capsule, the course of treatment for 1 month, the results of the test group total effective rate was 82.19%; the control group total effective rate was 59.57%, the difference is statistically significant.