As we all know, the key to pregnancy is the combination of the female egg and the male sperm to form a fertilized egg that will be laid in the uterus and develop slowly. This is the time to be alert to the possibility of unruptured follicle luteinization syndrome. Unruptured follicular luteinization syndrome is a condition in which the follicles mature but do not rupture, and the oocytes are not expelled but luteinize in situ, forming the corpus luteum and secreting progesterone, with a series of changes in the body effector organs similar to the ovulatory cycle. It is characterized by normal or prolonged menstrual cycles with ovulation-like manifestations but persistent infertility. It is a specific type of anovulatory menstruation and is one of the most important causes of infertility. Many people find out that they have this disease when they repeatedly fail to ovulate naturally after normal growth and maturation of follicles or after the application of ovum breaker injections. There are many causes of LUFS, such as: ① endometriosis with repeated bleeding causing adhesions around the ovaries if the lesion is located on the ovaries; ② pelvic inflammatory disease with the formation of fibrinous adhesions wrapping around the ovaries. In these cases, even though the ovum has been discharged outside the white membrane, it is still wrapped in the adhesion zone which is close to the surface of the ovary; (3) In patients with polycystic ovary syndrome, the central sex hormone secretion is disturbed and LH is abnormally increased, which stimulates the follicular endometrial cells and interstitial cells of the ovary to synthesize a large amount of androgens. (4) hyperprolactinemia; (5) external factors such as drugs; and (6) psychosomatic factors. How is LUFS treated? In vitro fertilization and embryo transfer is the best treatment option, also known as IVF, where the ovum that cannot be removed is removed by puncture and combined with sperm outside the body to form a fertilized egg that is then transferred back into the uterus for pregnancy.