Treatment of hemorrhoids with metronidazole alone is ineffective; metronidazole is mostly used as an adjunctive treatment for hemorrhoids and can be used for postoperative infection control and prevention. Some studies have shown that postoperative spasm of the internal anal sphincter and secondary infection of the surgical site often occur after hemorrhoid surgery, and metronidazole has the effect of preventing infection and stopping the surgical wound from being infected by intestinal anaerobic bacteria. However, it should be noted that if symptoms of adverse reactions such as rash, fever, nausea and vomiting occur after the use of this drug, it is recommended to stop using the drug and seek medical attention. The use of the drug is prohibited in cases such as early pregnancy, having taken disulfiram within the last two weeks. The appearance of hemorrhoids, it is recommended to promptly go to the hospital; metronidazole needs to be used under the guidance of clinicians.