Glans cancer and glansitis are only the same in terms of location, both are on the glans and the inner plate of foreskin. However, there is a substantial difference in the substance of their diseases, as glans cancer is a malignant tumor, while glansitis is just a common inflammatory infection.1. In terms of symptoms. Penile cancer usually manifests as small hard nodules, or solid warty protrusions, and deep or shallow, very incurable ulcers can be seen at the base of the lumps, and there will be bloody, foul-smelling discharge, and there will be urine outflow if the urethra is damaged. Circumcision, on the other hand, is only a superficial ulcer or itchy pain on the surface of the foreskin mucosa, sometimes accompanied by white discharge. 2. In terms of the cause of the disease. Glans cancer is usually related to viral infection, such as herpes simplex, genital herpes or condyloma acuminatum, and also diseases like penile leukoplakia can also induce glans cancer. Glansitis is usually related to the unhygienic condition of the patient, or local circumcision and long foreskin, forming inflammatory infection, usually related to foreskin scale.3. In terms of the result of treatment, glansitis has a good prognosis. Glansitis has a good prognosis and can return to normal after cure, while glans cancer usually has a bad effect after cure and can cause significant local damage, which often needs to be removed surgically.