The mortality rate of acute severe pancreatitis can reach 20-30%. This is because the disease of pancreatic cancer is easily complicated by abdominal cavity infection, disturbance of the internal environment, which can easily induce abdominal interval hypertension syndrome, while leading to liver and kidney insufficiency. The entry of bacterial toxins into the bloodstream is also prone to infectious shock, respiratory failure and acute respiratory distress syndrome in severe cases, and eventually also complicated by systemic inflammatory response syndrome, so the mortality rate of acute severe pancreatitis is very high. For patients diagnosed early, combined anti-infective treatment, intravenous nutritional support, surgical incision and drainage, abdominal lavage, removal of infected foci if necessary, and in severe cases, ventilator support therapy and monitoring of changes in the indicators of the internal environment are also options.