Coronary heart disease and cardiac neurosis are different in terms of the incidence of population, etiology, clinical manifestations, and auxiliary examination results. 1. The incidence of the population: cardiac neurosis occurs mostly in middle-aged and young people; women are more common than men, especially in menopausal women. Coronary heart disease occurs more often in adults over 40 years old, and the onset of male is earlier than that of female. 2. Etiology: The cause of cardiac neurosis is still unclear, and may be related to neurotypes, environmental factors, genetic factors and personality. The patient’s neurological type is often depression, anxiety, sadness. When mentally stimulated by the external environment may develop. Coronary heart disease is a heart disease caused by atherosclerosis of the coronary arteries, resulting in narrowing or occlusion of the lumen, leading to myocardial ischemia, hypoxia or necrosis. 3. Clinical manifestations: cardiac neurosis pain site is not fixed, mostly confined to the apical region and the left submammary region is very small range; mostly in the resting state when the onset of nitroglycerin can not be relieved. Coronary artery disease pain is pressing or burning pain in the precordial area, which can be radiated to the left shoulder and left forearm, accompanied by palpitations and shortness of breath. It occurs after exertion and can be relieved by taking nitroglycerin. 4. Auxiliary examination: patients with cardiac neurosis do not have evidence of organic heart disease, and no clear abnormality can be seen in heart-related examination. Coronary artery disease patients have symptoms and signs consistent with cardiac ultrasound, electrocardiogram, cardiac enzymology and other tests can be seen abnormal. If the patient has any uncomfortable symptoms, he should go to the hospital in time to get a clear diagnosis so as not to delay the treatment.