In clinical practice, canker sores refer to acute appendicitis, which is a common clinical condition and the most common acute abdominal condition. In general, acute appendicitis is associated with blockage of the appendiceal lumen and bacterial invasion. There are many etiologies that cause obstruction of the appendiceal lumen in patients, such as significant hyperplasia of lymphatic follicles, fecal stones, foreign bodies, inflammatory strictures, food debris, tumors, and roundworms. When the appendiceal lumen is obstructed, the pressure in the appendiceal lumen rises and the patient’s appendix becomes obstructed in blood flow, leading to appendicitis; after the appendiceal lumen is obstructed, bacteria take the opportunity to multiply and secrete endotoxins and exotoxins, which damage the mucosal epithelium of the patient’s appendix and cause ulceration of the mucosa, leading to infarction and gangrene of the appendix. In general, the causative organisms are mostly gram-negative bacilli and anaerobic bacteria in the intestinal tract. If the patient is diagnosed with appendicitis, prompt surgical removal is recommended so that the patient’s life is not in danger.