The difference between chronic nephritis and purpura nephritis mainly lies in the differences in pathogenesis, symptoms and treatment modalities. 1. Pathogenesis: The vast majority of chronic nephritis develops from primary glomerular diseases of different etiologies, and only a few chronic nephritis develops from acute nephritis. While purpura nephritis is generally due to renal damage caused by allergic purpura. 2. Symptoms: chronic nephritis with proteinuria, hematuria, hypertension and edema as the basic clinical manifestations, the mode of onset varies, the condition of the delay and slow progress, there may be varying degrees of renal function damage, some patients eventually developed into uremia. Purpura nephritis may have symptoms such as skin purpura, hematuria, and renal hypoplasia. 3. Treatment: Chronic nephritis can be treated with medication, and if the kidney function is seriously damaged, dialysis or kidney transplantation can be chosen according to the condition. The treatment of purpura nephritis generally includes medication, plasma exchange therapy and so on. Patients with chronic nephritis or purpura nephritis are advised to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.