Low-concentration atropine for myopia control

      According to a multi-year study conducted by the National Eye Institute of Singapore, atropine has been shown to be effective in delaying myopia, which is one of the three evidence-based measures that are currently effective in delaying myopia: keratoplasty, atropine, and 2 hours of daily outdoor activity. According to a recently published article on the META analysis of atropine for myopia delay (a META analysis is a summary of many scientific articles and a META analysis of their effectiveness, safety and other aspects), it was concluded that atropine significantly delayed myopia progression, more so in Asian children than in white children. This effect was not related to differences in drug concentration.  Because atropine has such a wide range of effects, those that are not controlled by myopia are called “side effects,” and currently we can only reduce these “side effects” by applying lower concentrations. Some of the domestic atropine drops are 1% and need to be diluted. The diluent is ALCON eye drops, and since both are packaged in 5ML, dilution is not too difficult and can be done by simple calculation. The concentration that can be used is 0.01% – 0.1%, that is, diluted 100 times to 10 times, so the amount of 1% atropine liquid extracted is 0.05ML to 0.5ML (use a 1ml syringe) mixed into Siran eye drops, ready to use, one in a month. The recommended starting concentration is 0.01% or 0.02% (0.05ML and 0.1ML of 1% atropine), and the usage is once every other day to observe the child’s reaction before deciding whether to use it once a day or once every other day. The eye axis was tested for 3 months to monitor the growth of myopia. The concentration and dosage of each child’s medication is individualized, so we can only try it slowly and then adjust it, so please keep good records. Because there is no ready-made low-concentration atropine in China, so parents can only solve it by themselves. I can help you observe the effect of the drug and adjust the medication method, and I hope this will be useful for children to control myopia. But because this is the OFF-LABEL drug, parents should also understand.  Precautions for ordering atropine eye solution: 1. After ordering, press the inner corner of the eye for 3 minutes to prevent atropine from entering the nasal cavity for absorption from the lower tear dots.  2. Atropine can cause pupils to dilate to varying degrees, so children may have photophobia, but of course the lower the concentration, the less obvious it is, but it varies according to the individual.  3. Atropine can cause paralysis of the ciliary muscle, which may cause problems when looking close. Again, the lower the concentration, the less pronounced it is, and it depends on the individual.