Condyloma-like changes, which refer to manifestations similar to condyloma acuminata, usually occur in the moist areas of the skin and mucous membrane around the external genitalia and anus. It typically has a soft texture with a sharp, reddish papule at the tip, which can later become more numerous and larger, with a lumpy surface, and some patients present with a papillary, cauliflower, or corkscrew shape. The warts are divided into red or white, and the surface is prone to erosion, oozing, and rupture. It is important to note that there are some clinical conditions that need to be distinguished from warts, such as syphilis patients in the second stage of syphilis, can occur flat warts, also in the perianal and external genital area, mainly manifested as flesh-red flat papules or plaques, the surface vesicles, moist, or can be lightly crusted.